Acute pancreatitis has a variety of pathogenic risk factors, domestic biliary tract disease dominates, accounting for more than 50%, called biliary pancreatitis. Western mainly related to excessive alcohol consumption, accounting for about 60%. 1, biliary tract disease: bile duct stones moving down can block the end of the common bile duct, when the bile can be refluxed through the “common channel” pancreatic duct, which by the role of bacteria will be combined with bile acids reduced to free bile acids can damage the pancreas, and can be activated in the pancreatic fluid phospholipase A into phospholipase A, which causes pancreatic tissue necrosis, resulting in acute This causes pancreatic tissue necrosis and acute pancreatitis. The causes of obstruction at the end of the common bile duct include biliary roundworms and edema or stenosis of the duodenal papilla caused by inflammation or surgical instruments. 2, excessive alcohol consumption: excessive alcohol consumption is the main risk factor for the disease in the United States. In addition to direct damage to the pancreas, alcohol can stimulate pancreatic secretion and cause duodenal papillary edema and spasm of the sphincter of Oddi, which results in increased pressure in the pancreatic duct, rupture of the small pancreatic duct, and pancreatic fluid into the tissue around the alveoli. At this time, trypsinogen is activated by collagenase into trypsin, which in turn activates phospholipase A, elastase, chymotrypsin and pancreatic diastase to “self-digest” the pancreas and acute pancreatitis occurs. 3, duodenal fluid reflux. Traumatic factors: blunt force trauma to the upper abdomen, penetrating injuries, surgical operations, especially operations via the Vater’s vagina, such as endoscopic retrograde cholangiopancreatography and endoscopic choledochotomy via the Vater’s vagina. 5, pancreatic blood circulation disorders: hypotension, cardiopulmonary bypass, arterial embolism, vasculitis and increased blood viscosity can cause acute pancreatitis due to pancreatic blood circulation disorders. 6, other factors: there are many risk factors for pancreatitis, such as dietary factors, infectious factors, drug factors, and metabolic, endocrine and genetic factors related to hyperlipidemia, hypercalcemia, pregnancy, etc. In addition to the above causes, a few acute pancreatitis can not find a cause, called idiopathic pancreatitis.