Acute pancreatitis is a sudden disease that has a great impact on human health. There are many causes of acute pancreatitis, such as gallstone disease, heavy alcohol consumption, overeating, blocked blood vessels, infection, trauma, metabolic diseases, and genetic factors. Acute pancreatitis is closely related to gallstone disease because the pancreatic duct and common bile duct converge and open together in the jugular abdomen of the duodenum. In the case of gallstones, the stones will be embedded in the jugular abdomen causing protein thrombosis in the pancreatic duct, which leads to acute pancreatitis. In the case of heavy alcohol consumption, alcohol will stimulate the pancreas to secrete a large amount of pancreatic enzymes, causing a sudden rise in pressure in the pancreatic duct causing the rupture of the pancreatic vesicles and the entry of pancreatic enzymes into the interstitial space between the vesicles and promoting acute pancreatitis. In addition, people who overeat and binge eat will let a large number of chyme into the duodenum in a short period of time, and when the pancreatic and bile excretion is not smooth, acute pancreatitis will easily occur. Trauma to the pancreas can lead to rupture of the pancreatic ducts, spillage of pancreatic fluid and inadequate blood supply after trauma, which can also lead to acute heavy pancreatitis. In addition, some metabolic diseases and genetic factors may also lead to the development of acute pancreatitis. After the causes of acute pancreatitis are clarified, we should pay special attention in our daily life and develop good eating habits to minimize the chances of acute pancreatitis attacks.