The hand touches the water for a few minutes and wrinkles, the reason for this situation is usually the nerve and vascular reflex when the hand is immersed in water, which is usually a normal phenomenon and can recover on its own within a short time. If the recovery time is longer may also be due to dry skin, skin barrier damage and collagen content reduction, etc.: a. Normal: normal skin gaps exist between, water relative to the cellular fluid and tissue fluid is a hypotonic liquid, can be inhaled into the skin gaps, hands in water immersion time is too long to inhale more water can appear wrinkles. May also be due to the hand stimulated by water, caused by the nerve, vascular reflexes, resulting in dermal vasoconstriction skin folding phenomenon, usually belongs to the normal phenomenon, no special treatment. Second, the abnormal situation: 1, dry skin: dry skin can promote the skin interstitial inhalation of more water, thus causing the skin of the hand folds; 2, damaged skin barrier: due to allergies or excessive use of bleach, soap and other substances, resulting in damage to the skin barrier of the hand, so that the sebaceous membrane to play a protective role is destroyed, thus causing the skin corneal layer to absorb water swelling, resulting in skin folds; 3, collagen Content reduction: the content of intracellular collagen is not enough to support the cytoskeleton, can also lead to wrinkles in the skin when the hand touches the water; 4, other: eczema, dermatitis and other local skin tissue damage, vitamin B deficiency and lack of nutrients in the body, such as hypoalbuminemia, etc., usually may also cause the hand to touch the water easily wrinkled phenomenon, you can seek medical examination to help confirm the diagnosis.