The presence of high creatinine in diabetes usually indicates the possibility of diabetic nephropathy, diabetes mellitus combined with renal disease, etc. It is necessary to go to the hospital for further examination to clarify the cause of the disease, and then consult the doctor in time. 1. Diabetic nephropathy: It is one of the most common microvascular complications of diabetes. If the blood sugar is not well controlled for a long time, it may lead to damage of the kidney and develop into diabetic nephropathy. Therefore, diabetic patients may have high creatinine. 2. Diabetes combined with renal disease: If the patient himself suffers from diabetes and renal disease, such as glomerulonephritis, nephrotic syndrome, etc., with the progression of the disease, the renal function continues to be impaired, which may lead to creatinine increase. Therefore, diabetic patients may also have elevated creatinine. When diabetic patients with elevated creatinine, it is recommended to go to the regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.