Hepatitis combined with hyperthyroidism is prone to develop into severe hepatitis, which should be given enough attention clinically to avoid aggravation of the condition. The liver is involved in the inactivation process of thyroxine. Excessive thyroxine forms a high metabolic state in the body, oxygen consumption increases, and the increase in hepatic catabolism can aggravate the burden on the liver and cause further deterioration of liver function. Antithyroid drugs such as methylthiouracil, propylthiouracil, tabazole, etc. are metabolized in the liver, which can also aggravate the burden on the liver, and long-term use of these drugs can form pharmacological liver damage and contribute to the deterioration of liver function. Therefore, in the treatment of patients with hyperthyroidism combined with hepatitis, anti-hyperthyroidism drugs such as propylthiouracil or tabazole and cardiac glycosides can also be used, but liver function and thyroid function need to be closely observed, and the rational use of antithyroid drugs is conducive to the recovery of liver function. In the long-term use of antithyroid drugs in patients, need to frequently measure FT3, FT4 and TSH, such as the existence of drug liver damage is considered, should be promptly discontinued antithyroid drugs, switch to the use of Xindean, lithium carbonate and other less common damage to liver function of the control of hyperthyroidism, hyperthyroidism is still poorly controlled can be oral iodine uptake rate measurement, if necessary, the feasibility of radioactive iodine 131 treatment, but must pay attention to the hyperthyroidism of crisis. However, attention must be paid to the occurrence of hyperthyroidism crisis. For some cases of severe hepatitis combined with hyperthyroidism, radioactive 131 iodine has been used to control hyperthyroidism, which is not suitable for anti-hyperthyroidism drugs or anti-hyperthyroidism drugs cannot control hyperthyroidism, which has achieved good efficacy and lowered the case fatality rate.