Many tumors in the late stage, bone metastasis will occur. The sites where bone metastasis occurs are mostly in the mid-axis bone and lower limbs, especially in the thoracic and lumbar vertebrae and sacroiliac hip regions, and commonly include breast cancer, lung cancer, prostate cancer, kidney cancer, colorectal cancer, pancreatic cancer and so on. Cao Wenlan, Department of Oncology, Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine The severe pain of bone metastasis is due to the release of relevant factors by the tumor, which increases the activity of osteoclasts and forms osteolytic bone destruction. The tumor cells secrete some pain mediators such as prostaglandins, lactic acid, interleukin II and tumor necrosis factor, etc. The tumor invades the periosteum, peripheral nerves and soft tissues, among which the activation of osteoclasts plays a key role. Bone fracture and spinal cord compression paralysis are more common serious accompanying events for patients with bone metastases, which obviously affect their quality of life. We suggest such patients, to bring information to the outpatient clinic as soon as possible, and if it is possible to choose radiotherapy, it will give you unexpected surprises.