Patients with fatty liver can present with a slightly enlarged liver and spleen, and can have normal aminotransferase levels. Patients with fatty liver are usually found to have fatty infiltration on the surface of the liver during an ultrasound examination. Patients with fatty liver may have normal or elevated aminotransferase levels, with elevated aminotransferase levels suggesting a necrotizing inflammatory response in the liver, and it is common for the liver to be slightly enlarged during ultrasound. Patients with fatty liver usually do not have splenomegaly. When splenomegaly occurs, it is considered that the patient’s fatty liver is more serious, and after the liver is infiltrated by fat cells, the portal vein will widen, and there will be blood reflux in the portal vein, which will lead to splenomegaly. A small percentage of patients with fatty liver may also develop cirrhosis secondary to splenomegaly, which requires active treatment of fatty liver and intervention through diet and exercise is recommended. Patients with fatty liver who develop enlargement of the liver and spleen are also advised to seek treatment in the gastroenterology department of the regular hospital.