Symptoms of advanced diabetic renal failure are mainly manifested as cardiovascular system manifestations, respiratory system symptoms, gastrointestinal symptoms, neuromuscular system symptoms and so on. 1. Cardiovascular system: hypertension, left ventricular hypertrophy, heart failure, uremic cardiomyopathy, pericardial lesions, vascular calcification and atherosclerosis are more common. 2. Respiratory symptoms: shortness of breath and shortness of breath can occur in fluid overload or acidosis, and severe acidosis can lead to deep and long breath. Excessive fluid and cardiac insufficiency can cause pulmonary edema or pleural effusion. Increased permeability of alveolar capillaries and pulmonary congestion induced by uremic toxins can cause uremic pulmonary edema. 3. Gastrointestinal symptoms: the main manifestations are lack of appetite, nausea, vomiting, and the taste of urine in the mouth. Gastrointestinal bleeding is also more common, and the incidence is significantly higher than normal, mostly due to gastric mucosal erosion or peptic ulcer. 4. Neuromuscular system symptoms: early fatigue, insomnia, inattention, followed by personality changes, depression, memory loss, reduced judgment. When uremia is severe, there are often indifference, delirium, convulsions, hallucinations, coma, mental anomalies and other manifestations, that is, uremic encephalopathy. In addition, diabetic diabetic renal failure in the late stage can also appear water, electrolyte disorders and other symptoms. It is recommended that patients seek medical treatment as soon as possible and follow the doctor’s instructions to avoid aggravation of the condition.