Chronic mastitis during non-lactation remains a challenge in breast surgery. It includes periductal mastitis (PDM) and granulomatous mastitis (GM). Periductal mastitis is also known as plasmacytic mastitis because of the large number of plasma cells infiltrating the tissue surrounding the inflammation as the main feature. Plasmacytoid mastitis is a more complex inflammatory disease of the breast. The lesions are mostly near the areola and are locally red, swollen and painful. There is usually no fever. In some patients, the lumps become large rapidly in about 5-7 days, with more than 10cm, a few can subside on their own, and then again when the resistance is low due to exertion, colds, etc., but once more than once, the lumps gradually become larger, red and swollen, some doctors treat as ordinary mastitis breast abscess, the effect of treatment with antibacterial agents is not significant; finally incision and drainage, so that a fistula is formed, difficult to heal. Sometimes the redness breaks down on its own and also remains untreated for a long time. The cause of plasmacytic mastitis may be related to nipple invagination or dysplasia, breast trauma, lactation disorders, endocrine disorders and degenerative changes in the breast and antidepressants. The inflammation is centered in the areola and is closely related to the large ducts behind the areola, which may form sinus tracts or fistulas. Granulomatous mastitis is related to autoimmune diseases, use of contraceptive drugs, trauma, infection and chemicals that irritate and destroy the milk ducts, causing glandular secretions, milk and keratinized epithelium to escape into the lobular mesenchyme and cause an inflammatory response. It is mostly a peripheral mass with a tunneling pattern spreading throughout the breast. Sinus tracts may form without fistulas. Treatment of non-lactating chronic mastitis is currently tricky. Chinese medicine, puncture and pus extraction, and incision and drainage of pus do not solve the problem at all, and the more treatment is given, the more complicated the condition becomes. Surgical radical mastectomy provides rapid relief with less chance of recurrence, but the disadvantage is that the shape of the breast may change, especially for larger lumps. Another treatment option for patients with complex sinus tracts that remain untreated for a long time and have high requirements for breast appearance is triple anti-TB treatment, which can partially preserve breast appearance.