With the development of society, increasing social pressure and environmental problems brought about by industrialization have caused an increase in the incidence of many diseases, including infertility patients have also increased significantly, foreign data show that the incidence of infertility in couples of childbearing age in Western countries has increased from 7% to 8% in the 1960s to 15% to 20% in recent years, of which 20% is caused by male factors alone, and the remaining 30% to 40% is related to male factors. Male infertility patients are almost the most common patients in the male clinics of major hospitals. At the same time, the prevalence of premature ejaculation among men is also high, about 14% to 41%, and 75% of men will experience premature ejaculation in their lifetime, so we often encounter male infertility patients with premature ejaculation in the clinic, and these patients are very concerned about whether premature ejaculation affects fertility. In general, premature ejaculation does not affect fertility. As long as male infertility patients with premature ejaculation are able to ejaculate in the vagina and have a normal frequency of sex, then this situation only affects the quality of sex life and does not affect fertility because it does not interfere with the entire physiological process of sperm and egg meeting in the female oviduct, sperm-egg union to form a fertilized egg and then embryo formation and implantation. For such patients, behavioral therapy, medication and other measures for premature ejaculation can be used while treating infertility to achieve the goal of both helping patients solve their fertility problems and improving the quality of their sex life. However, in some special cases, such as when premature ejaculation causes patients to have less frequent sex or to be unable to ejaculate in the vagina, fertility may be affected. Although premature ejaculation itself generally only affects the quality of sexual life and does not affect fertility, it may affect fertility if the patient does not have sex because he or she is worried about premature ejaculation, or if he or she reluctantly has sex but very infrequently or avoids female ovulation; it may also affect fertility if the patient ejaculates outside the vagina. For such patients, it is best if the above measures are taken to solve both fertility and premature ejaculation problems; if the problem of premature ejaculation cannot be solved temporarily and fertility problems must be solved as soon as possible, external ejaculation can be performed in a clean container and then injected into the woman’s vagina with a syringe, which is equivalent to artificial insemination at home, and if this does not work, further treatment measures should be taken at the hospital. Premature ejaculation generally does not affect male fertility, but if it results in a low frequency of sex or inability to ejaculate in the vagina, it may affect fertility, and we can take appropriate measures to solve both the fertility and premature ejaculation problems of the patient.