Chronic pancreatitis for more than 40 years to actively find the cause of the disease, for the cause of the treatment, often including general treatment, pancreatic exocrine insufficiency of the treatment, pancreatic endocrine insufficiency of the treatment, pain treatment and surgical treatment. 1. General treatment: abstain from alcohol and smoking, avoid high-fat and high-protein diets, and exercise appropriately. If there is malnutrition, which cannot be improved by oral intake, enteral or parenteral nutritional therapy can be carried out. 2. Treatment of pancreatic exocrine insufficiency: if patients have steatorrhea, weight loss and other manifestations, exogenous pancreatic enzyme preparations can be supplemented, preferred compound digestive enzymes and so on, in order to improve the patient’s digestive and absorptive functions. 3. Treatment of pancreatic endocrine insufficiency: patients with diabetes can choose metformin or insulin for treatment. 4. Pain treatment: antioxidants and painkillers can be chosen for analgesic treatment, such as vitamin E and acetaminophen. The choice of pain medication should be from weak to strong, and try to give medication orally. 5. Surgery: If conservative treatment fails to relieve the condition or if it is accompanied by pancreatic duct stenosis or obstruction, surgical treatment can be carried out. According to the condition, endoscopic intervention, pancreatectomy, pancreatic duct drainage and other surgical methods can be chosen. Repeated episodes of chronic pancreatitis can be complicated by bile duct stenosis, pancreatic fistula, pancreatic pseudocysts and other diseases, and it is recommended to actively treat them to improve the quality of life.