There are many ways to treat thrombophilia in the elderly, the first one, anticoagulation therapy. Anticoagulation therapy can reduce blood coagulation, stop the extension or expansion of thrombus, dissolve the formed thrombus through its own fibrinolytic system, and reopen the blocked blood vessel, commonly used drugs include heparin, low molecular heparin, warfarin, etc. The second, thrombolytic therapy. Thrombolytic therapy is to actively dissolve the formed thrombus and reopen the blocked blood vessel, there are two ways of systemic thrombolytic therapy and local interventional thrombolysis, commonly used drugs include streptokinase, urokinase, etc. The third one is antiplatelet therapy. Platelets play an important role in the process of arterial thrombosis, and commonly used are aspirin, clopidogrel and cilostazol. In addition to drug treatment, there are also surgical and interventional treatment methods. For the elderly, it is important to perform the above treatments with attention to the indications and contraindications of the treatment, and especially to the side effects of bleeding.