In 1909, Noon’s successful treatment of hay fever rhinitis with autoimmunotherapy ushered in a new era of immunotherapy. After more than half a century of practice, immunotherapy showed some clinical effectiveness, but since the 1980s, several cases of death due to injection of immunotherapy agents occurred in the United Kingdom, leading to a total ban on immunotherapy ordered by the relevant government agencies. The first successful treatment of allergic rhinitis using sublingual desensitization therapy (i.e., sublingual specific immunotherapy (SLIT)) by Scadding and Brostoff in 1986 gave renewed hope for immunotherapy. In 1992, the World Health Organization (WHO) confirmed the effectiveness of immunotherapy for type I allergic diseases through an evidence-based approach and concluded that “it should be applied as soon as possible if conditions are available”, and immunotherapy was reintroduced. In 1993, the European Academy of Allergic and Clinical Immunology (EAACI) pointed out that sublingual specific immunotherapy (SLIT) could be a potentially valuable treatment. In 1998, the WHO Opinion on Allergen Immunotherapy pointed out that “desensitization is the only possible cure for allergic diseases” and formally recommended the effectiveness and safety of sublingual specific immunotherapy. Currently, sublingual desensitization is being promoted in Europe and the United States, while subcutaneous immunotherapy is fading out of mainstream medical treatment due to its potential hazards. In 2001, the Global Initiative for Asthma Control (ARIA) confirmed the safety of sublingual desensitization with high doses of allergens (at least 100 times the cumulative dose of subcutaneous immunotherapy) for children and adults. In 2004, the World Health Organization endorsed SLIT as one of the main treatments for certain allergic diseases such as allergic asthma and allergic rhinitis. 13.2 Academician Zhong Nanshan On July 8, the first World Allergy Day, Academician Zhong Nanshan, President of the Chinese Medical Association, pointed out that more than 200 million people in China suffer from allergic diseases, and desensitization has been recognized as a highly effective treatment. Zhong Nanshan academician introduced that 22% of the world’s population is suffering from allergic rhinitis, asthma, eczema and other allergic diseases, and the rate of increase is 23 times every 10 years, and is expected to reach 40% of the global population in 2010. By analogy, there are currently more than 200 million people suffering from allergic diseases in China, which should be taken seriously. The antigen that triggers an allergic reaction is called an allergen. Allergens are necessary for allergies to occur. There are 2,000-3,000 common antigenic substances that cause allergic reactions, and close to 20,000 in the medical literature. They are inhaled, ingested, injected or contacted to cause allergic phenomena in the body. Common allergens are as follows: A. Inhalation allergens: such as pollen, willow wool, dust, mites, animal dander, oil smoke, paint, car exhaust, gas, cigarettes, etc. B. Ingested allergens: such as milk, eggs, fish and shrimp, beef and mutton, seafood, animal fat, allogeneic proteins, alcohol, drugs, antibacterial agents, anti-inflammatory drugs, fragrance oils, flavors, onions, ginger, garlic, and some vegetables, fruits, etc. C, contact allergens: such as cold air, hot air, ultraviolet light, radiation, cosmetics, shampoo, detergent, hair dye, soap, chemical fiber products, plastic, metal jewelry (watches, necklaces, rings, earrings), bacteria, mold, viruses, parasites, etc. D, injectable allergens: such as penicillin, streptomycin, heterologous serum, etc. E. Self-tissue antigens: Self-tissue antigens affected by biological and physical and chemical factors such as mental tension, work stress, microbial infection, ionizing radiation, burns, etc., and self-hidden antigens released due to trauma or infection can also become allergens. The most effective measure to treat persistent allergies is to find allergy triggers (allergens), but to find the exact causative factor among 20,000 different triggers is like looking for a needle in a haystack. The latest authoritative experiments have confirmed that the number of free radicals in the body of allergic people is much higher than that of non-allergic people! Free radicals are the basis for the formation of allergic body. They also directly oxidize the mast cells and basophils in the body, causing the cell membrane to rupture and release histamine, resulting in allergic reactions. Therefore, to improve the allergic body must remove free radicals. Free radicals come from two sources: one is in the body itself in the process of oxidative metabolism constantly produced; second, environmental pollution, radiation, bad habits, etc., will also continue to produce free radicals. Free radicals can be called the source of all evil, the culprit of all diseases. The aging of human body and many diseases are closely related to them. The lipid peroxides formed by free radicals can damage biological membranes, destroy cells, hinder normal metabolism, accelerate aging, and cause diseases such as immune imbalance, allergies, stubborn dermatitis, rhinitis, conjunctivitis, asthma, eczema, hypertension, myocardial infarction, diabetes, hepatitis, gout, nephritis, cataracts, and many others. In the current hospital tests, just checking 50-100 allergens is far from comprehensive, but we can completely change our own allergic constitution through the GLP desensitization factor series. The World Health Organization WHO clearly states in its guiding document on immune desensitization therapy that “immune desensitization therapy is the only radical treatment for allergic diseases”. International allergy research authorities also suggest that “the use of high-quality standardized desensitizing agents should be accompanied by an optimal allergy treatment program that includes allergen removal, patient immune repair, appropriate symptomatic medication for allergic co-inflammation, and immunotherapy with standardized desensitizing agents, referred to as the “four-in-one quadruple therapy The “four-in-one quadruple therapy” protocol.