Prolonged chest pain may be caused by pleural effusion, coronary heart disease and breast fibroma, etc. It can be treated with oral antibiotics, antiplatelet and other drugs and surgery as prescribed by the doctor. 1. Pleural effusion: Pleural effusion caused by pneumonia can stimulate the pleura and cause prolonged chest pain, which is caused by inflammation of the lungs. Oral antibiotic drugs, such as cefuroxime, azithromycin, etc., can be taken as prescribed by the doctor, with puncture and fluid extraction treatment if necessary. 2. coronary heart disease: coronary heart disease can cause frequent chest pain, coronary heart disease is a long-term chronic disease, coronary ischemia can cause frequent chest pain. Oral antiplatelet drugs, such as aspirin and clopidogrel bisulfate, can be prescribed. 3. Breast fibroma: breast fibroma has no manifestation of chest pain in the early stage, and prolonged chest pain will appear only with the enlargement of tumor. Breast fibroid patients, generally do not advocate taking medication. Patients with fibroid tumors over 1cm are recommended to have surgery. Patients with prolonged chest pain, it is recommended that patients go to the hospital in time to find out the cause of the disease, according to the cause of the standardized treatment, taking drugs need to follow the doctor’s instructions.