Abstract: [Objective] To compare the efficacy and side effects of two doses of MTX in patients with early tubal pregnancy in two groups: 50 mg group and 100 mg group, using the treatment method of hysteroscopic tubal cannulation with MTX. [Methods]: From 01 to 07, 2007, 49 patients with early tubal pregnancy eligible for conservative drug treatment were randomly divided into two groups, including 23 cases in the 50 mg group and 26 cases in the 100 mg group, using the above method to compare the efficacy. [Results]: The success rate of the 50 mg group was 82.61% (19/23), the incidence of adverse drug reactions was 30.43%, the tubal patency rate was 100%, the average hospitalization days were 23.74±3.68 days, and the hospitalization cost was 6422.48±1142.27 yuan; the 100 mg group was 84.61%, 42.31%, 100%, 14.46± 2.96 days , 5059.03±964.47 yuan. [Conclusion]: The success rate, incidence of side effects and tubal patency rate of early tubal pregnancy treated by hysteroscopic intubation with 100 mg MTX were not significantly different from those of the 50 mg group, but the number of hospital days and hospital costs were significantly reduced, which can save a lot of labor and material resources for the society and is a minimally invasive, safe and socially more effective treatment option. As the incidence of pelvic inflammatory disease is on the rise, the incidence of tubal pregnancy secondary to tubal inflammation has also increased. Many of these patients are eager to preserve their natural reproductive function. With technological advances in the early diagnosis of ectopic pregnancy, there are now several conservative treatment options that are indeed feasible, among which the efficiency and safety of hysteroscopic tubal cannulation with methotrexate (MTX) has been confirmed by many reports. The reliability of this result is also supported by relevant data from our institution. Now we used hysteroscopic tubal cannulation with MTX to randomly divide the patients with early tubal pregnancy into 50 mg and 100 mg groups to compare the efficacy and side effects of the two groups in order to understand the advantages and disadvantages of the two treatment doses.