The human gallbladder has the function of concentrating, storing and emptying bile. Most of the bile secreted by the liver is stored in the gallbladder, and after we eat, especially after eating food containing a lot of fat, the gallbladder will contract and discharge bile into the intestine, which has the function of assisting digestion and absorption. If the gallbladder is removed, there is no place to store the bile, and the bile secreted by the liver will enter the intestine directly around the clock, resulting in an increase in the number of intestinal and hepatic cycles, and an increase in the contact between the primary bile acids in bile and intestinal anaerobic bacteria. The secondary bile acids, lithotrizoic acid, is a promoter of colorectal cancer, and deoxycholic acid can be converted into methylcholanthrene, which has been proved to be a powerful carcinogen. Foreign scholars have found that secondary bile acids have strong oxidizing effects, which destroy the genes of cells, reduce the resistance of cells to damage and undergo malignant transformation, and these factors will promote the cancer of intestinal mucosa. In China, some studies have been conducted on whether there is a relationship between gallbladder removal and colorectal cancer. Henan University Hospital conducted a retrospective analysis of colorectal cancer cases admitted from 1987 to 2002. 132 cases of colorectal cancer were admitted in 15 years, and 138 cases of other malignant tumors were selected from the control group in the same period. Among the 132 cases of colorectal cancer, 37 cases (28.03%) had previous cholecystectomy and gallbladder stones, while only 14 cases (10.15%) were in the control group, and the colorectal cancer group was significantly higher than the control group. A similar study was conducted in Suzhou University Hospital, in which 156 cases of colorectal cancer admitted from 1990 to 2002 were retrospectively analyzed, and the control group consisted of 550 cases of other tumors unrelated to gallbladder stones during the same period, among the 156 patients with colorectal cancer, 40 cases (25.6%) had previous cholecystectomy and combined gallbladder stones, while 35 cases (6.3%) were in the control group. It is easy to see from the findings that the incidence of colorectal cancer after gallbladder stones and cholecystectomy is significantly higher. Although today’s lumpectomy technology has become very convenient and safe for gallbladder removal, it is prudent to consider gallbladder removal for small stones with no symptoms or mild symptoms, gallbladder polyps less than 0.5 cm, and chronic cholecystitis without stones. Of course, although cholecystectomy may induce colorectal cancer, the current clinical incidence is not very high, so patients who have undergone cholecystectomy should not be too alarmed. Prevention mainly lies in diet, avoiding high-fat, high-protein and stimulating foods, especially less fried and deep-fried foods, minimizing the production of “secondary bile acids”, which are carcinogens in the intestine, preventing constipation, eating more fiber-rich vegetables and fruits, and drinking more water. Secondly, colonoscopy should be performed regularly to closely follow up and observe, so that colon cancer can be detected early and treatment can be taken in time.