1, Gaucher disease infantile type: mainly hepatomegaly, hypertonia, spasticity, no fundus cherry erythema, lymphocyte plasma without vacuoles, serum acid phosphatase is elevated, and Gaucher cells are found in the bone marrow. Wolman’s disease: no fundus cherry erythema, X-ray abdominal plain film shows enlargement of both adrenal glands, unchanged in shape, with diffuse punctate calcified shadows. Lymphocyte cytoplasm has vacuoles. 3.GM Gangliosidase Lipase Disease Type I: the appearance of birth, high forehead, low bridge of the nose, coarse skin, 50% of cases have fundus cherry erythema and lymphocyte cytoplasm with vacuoles. x-ray can see multiple bone hypoplasia, especially the vertebrae. Hurler’s disease (mucopolysaccharide type I): large liver and spleen, poor intelligence, lymphocyte cytoplasm with vacuoles, bone marrow with foam cells, etc. resembling NPD. cardiac defects, multiple bone hypoplasia, no pulmonary infiltration. Urinary mucopolysaccharide excretion increased, neutrophils have special granules. 6 months later appearance, bone changes obvious, vision loss, corneal clouding.