Spider moles on the legs may be caused by liver disease or hormone level imbalance, etc. According to the specific cause of the disease under the guidance of the doctor’s medication, as follows: 1. Liver diseases (1) Cirrhosis of the liver: it may be caused by chemical drugs, etc. Cirrhosis of the liver will damage liver cells, resulting in decreased ability of the liver to eliminate estrogen, so that the level of estrone hormone is elevated, and the elevated level of estrone hormone will cause the dilation of small arterial blood vessels, which will result in the growth of spider naevi on the legs, and will be accompanied by symptoms such as fatigue, and you can take medications such as entecavir or liver protection tablets to relieve the symptoms. (2) Hepatitis: It may be caused by irregular diet, etc. Inflammation stimulates the liver, which damages the liver and decreases the liver’s ability to eliminate estrogen, and increases 17β-estradiol, which dilates the small arterial capillaries and causes spider naevus on the legs, and is accompanied by abdominal distension, etc. You can take medicines such as adefovir or metadoxine to alleviate the symptoms. 2. Hormonal imbalance: Hormonal imbalance in the body will increase the level of estrogen and dilate the capillaries, thus causing spider moles on the legs. There may be other reasons for spider moles on legs, so it is recommended to have regular medical checkups, and have regular treatment as soon as possible after discovery.