Acute bronchitis is mostly caused by viruses and bacteria, and is usually characterized by cough and sputum as the main clinical manifestations. On examination, thickened breath sounds in both lungs can be heard, and chest imaging suggests increased, thickened and disturbed lung texture. If acute bronchitis is accompanied by cough and sputum that cannot be easily discharged, especially yellow sputum and little sputum that cannot be easily discharged, nebulization treatment can be added. Nebulization can relieve the symptoms of bronchospasm, promote the discharge of sputum, facilitate the absorption of bronchial infection, and shorten the course of the disease. The nebulization can be added with budesonide suspension and alpha interferon, which can play the role of anti-inflammatory, antispasmodic and asthma, stretching the bronchial smooth muscle and facilitating the discharge of sputum. alpha interferon can also increase the immune function of local respiratory tract infection to promote the absorption of the patient. In conclusion, acute bronchitis with sputum that is not easily discharged, accompanied by chest tightness and shortness of breath, can be given nebulization treatment with antibiotic therapy, which can effectively shorten the course of the disease and improve clinical symptoms.