Dry, rough skin on the hands, this condition may be formed by gradual aging of the skin, or local eczema and the formation of epidermal hyperplasia, or may be long-term exposure to alkaline detergents and toiletries, eventually causing damage to the corneal layer of the skin. Therefore, it is necessary to first reduce the number of hand washing, and also to reduce or not to use alkaline toiletries. If the dryness and roughness are accompanied by some cracking, topical application of mucopolysaccharide creams such as polysulfonic acid is also needed. It is also necessary to apply topical moisturizing creams, such as glycerin or 10% urea cream, or vitamin E cream.