Nuclear jaundice is a relatively serious neonatal disease, the main cause of the jaundice caused by neonatal hemolysis through the blood-brain barrier causing damage to the central nervous system, and according to the severity of the disease can be divided into four stages, if the development of the last stage of treatment, or very dangerous. 1, drug therapy: is suitable for the condition is relatively light, for the early nuclear jaundice children’s treatment, the main purpose of the main treatment is to reduce the end of the combined bilirubin-based, mainly for intravenous infusion, the specific type of drugs or need to be determined according to the actual situation of the child. 2, phototherapy: phototherapy is mainly a simple and safer effective way to treat nuclear jaundice disease, mainly by exposing the baby to blue light or white light for irradiation, which can increase the excretion of bilirubin. If the first two methods do not play a therapeutic role, it is necessary to consider blood exchange treatment, when the concentration of bilirubin in the baby’s blood exceeds a certain level, blood exchange is the most effective way. At present, the impact of nuclear jaundice on children is still very large, but also one of the most likely to form the sequelae of the disease, so that early detection, early treatment, can reduce the appearance of sequelae to a minimum.