. During pregnancy, vaginal discharge increases, but if there is a strong odor, vulvar itching, redness, or painful urination, it may be combined with bacterial vaginosis, candida vaginitis, or trichomonas vaginitis. Also other physiological or other pathological conditions can lead to increased vaginal discharge, such as vaginal metaplasia and decreased organismal resistance. Metronidazole is very effective in trichomoniasis and there is no significant difference in neonatal weight and gestational week of birth, and it does not increase the rate of preterm birth. A one-week course of miconazole ointment or econazole is similar to a two-week course, while a three-day course is not as effective as a one-week course. There is no information evaluating the safety of oral treatment of Candida vaginitis for use during pregnancy.