Mitochondrial diabetes is more serious. Mitochondrial diabetes mellitus is a special kind of diabetes mellitus, which is caused by mitochondrial DNA defects, mostly inherited from mother’s side, and can have a series of manifestations such as neurological deafness, paroxysmal vomiting, epileptic-like seizures, recurrent stroke-like episodes, thyroid function abnormalities, pseudo-obstruction of the small intestine, and total blood cell reduction. Mitochondrial diabetes mellitus is more serious and requires early prevention, diagnosis and treatment, and should be treated with insulin as soon as possible after diagnosis. Patients diagnosed with mitochondrial diabetes mellitus should actively cooperate with the doctor’s treatment, early detection and early treatment can improve the patient’s blood glucose situation and delay the development of complications.