A significant number of female infertility cases are due to non-ovulation, and polycystic ovary syndrome is the most common cause of female non-ovulation. A woman with normal menstruation expels an egg capable of fertilization in the middle of her two periods every month, which means that she has a chance to conceive once a month. In contrast, women with polycystic ovary syndrome often fail to produce an egg for several months due to ovulation disorders, thus reducing the chances of conception and even leading to infertility. Clinical manifestations mainly include menstrual disorders, infertility, hirsutism and obesity. With the changes in modern life, the incidence of the disease is gradually increasing. The pathological mechanism is mainly due to endocrine disorders that cause long-term ovarian failure to ovulate. As a result of non-ovulation, the level of luteinizing hormone is elevated and the level of follicle stimulating hormone (which is mainly used to promote follicle growth and development) is relatively low. The effect of high luteinizing hormone is that androgens are 50% to 150% higher than normal, which further inhibits ovulation; anovulation also leads to a lack of cyclic progesterone secretion, which in turn causes an increase in luteinizing hormone secretion, which in turn causes menstrual changes and impedes follicle development, forming a vicious circle. “This is a vicious circle. Some patients with polycystic ovary syndrome produce more insulin because they are insensitive to insulin. About 30% to 70% of patients have elevated insulin levels, which in turn stimulate the ovaries to synthesize more androgens, further inhibiting ovulation. The treatment of polycystic ovary syndrome is to take comprehensive measures to break the “vicious circle” of abnormal effects in multiple ways. Patients who are obviously obese should first lose weight, control their diet and exercise to reduce their weight. When the weight loss is 5%, the excessive androgens and insulin in the body can be reduced, and then menstruation can be restored, even ovulation, and even pregnancy. For women with fertility requirements who are not obese or whose weight loss is ineffective, if the fallopian tubes are open, medication can be applied to promote ovulation. Clomiphene is a non-steroidal drug with both weak estrogenic and anti-estrogenic effects and is the drug of choice for ovulation promotion in polycystic ovary syndrome. Ovulation mostly occurs when the drug is stopped for 7 to 10 days, when the patient is sexually traded for conception. If clomiphene fails to induce ovulation, tamoxifen (also known as triamcinolone) can be used, or alternated with clomiphene. Ovulation can also be induced with gonadotropins in patients with polycystic ovary syndrome who have failed for clomiphene treatment, but this should be done under close monitoring by a physician to prevent ovarian hyperstimulation syndrome. Pulsed subcutaneous or intravenous administration of gonadotropin-releasing hormone is another method of ovulation induction, but it is more expensive. Metformin is a drug for type II diabetes that increases insulin receptor sensitivity and lowers insulin and androgen levels. It is mainly used to treat obese, over-insulinized patients and usually works within eight weeks, with some patients regaining regular menstruation and ovulation and a few getting pregnant. After two months of taking metformin, she was given clomiphene to promote ovulation and ultrasound to monitor ovulation. In chronic anovulatory polycystic ovary syndrome, 10%-15% of patients do not respond to clomiphene ovulation promotion. If ovulation does not occur despite the addition of follicle stimulating hormone, ovarian perforation or ovarian wedge resection can be performed laparoscopically, and the condition of fallopian tubes can also be checked to restore ovulation and conception in some patients. For women who fail to conceive with the above mentioned medications, assisted conception techniques such as artificial insemination and in vitro fertilization can be used. In some patients who do not respond to ovulatory drugs or who overreact (overstimulation), in vitro human oocyte maturation techniques can be used to help them conceive, i.e., immature oocytes are extracted directly and matured in vitro for IVF to solve their fertility problems.