Bactroban, also known as mupirocin ointment, with mupirocin as the active ingredient, is a unique antibacterial preparation for the skin surface, primarily for the prevention and treatment of bacterial skin infections caused by gram-positive pathogens, especially Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA), and streptococci. It is commonly used for infectious diseases of the skin, such as abscesses, boils, folliculitis, etc. It can also be used for infections secondary to or combined with other skin diseases, such as eczema co-infection, ulcer co-infection, trauma co-infection, etc. It cannot be used for mucosal areas. It is less effective for acne because of its mild inhibitory effect on Propionibacterium spp. Bactrim has less effect on normal skin flora and its excipients are not obviously irritating, so the adverse reactions are mild, such as occasional local burning, stinging and itching, etc. Generally, there is no need to stop the drug, and allergic reactions are also rare. The systemic absorption of mupirocin by human intact skin is small, but it is excreted through renal metabolism after all, so it should be used with caution in patients with moderate to severe renal impairment. Pregnant women should also use it with caution; nursing mothers should pay attention to prevent the infant from importing it. Mupirocin has a unique antibacterial mechanism and is not cross-resistant with other topical antimicrobials, but its own resistance has increased in recent years due to its widespread application, so it is recommended to alternate with other antimicrobials to reduce the risk of drug resistance.