When blood uric acid is greater than 420 μmol/L for a long period of time, the gradual formation of gout stones is possible.
Uric acid is the end product of purine metabolism, produced through cellular metabolism by breaking down nucleic acids and other purine compounds. When the body temperature is 37℃, the saturation concentration of uric acid is about 420μmol/L. When the blood uric acid concentration exceeds this concentration, urate can form crystals, which are deposited in various tissues, such as kidneys, synovial membrane of joints, etc., causing tissue damage.
When urate crystals are slowly deposited, long-term damage to the tissues can cause monocytes, epithelial cells, macrophages infiltration, the formation of foreign body nodules, that is, gout stones.
Patients with high blood uric acid or gout stones are advised to go to the rheumatology and immunology departments of regular hospitals for detailed consultation and standardized diagnosis and treatment in accordance with the doctor’s instructions.