The so-called minor triple positive to minor bi-positive refers to the hepatitis B e antigen turning negative. Hepatitis B e antigen turning negative may be a good thing, but there is also the possibility of continued deterioration. This is to some extent a reflection of the results of the disease treatment, representing that the disease is getting better. After scientific treatment, hepatitis B infection has been controlled to a certain extent, which can be said to be a good thing. However, it does not mean that the disease has been recovered, but also need to carry out hepatitis B virus quantitative, liver ultrasound and other tests, for hepatitis B virus infection to carry out a comprehensive assessment of the progress of the disease can be determined. Meanwhile, Hepatitis B e antigen negativity may be temporary, and may change to minor triple positive at any time. Therefore, it is still necessary to be vigilant and pay attention to life care, such as eating a light diet, and follow the doctor’s instructions to carry out scientific treatment.