High-level DVT in the lower extremities in young people can be cured without surgery. The main treatment options for high-grade DVT in the lower extremities are thrombolysis and anticoagulation. High level thrombosis, also called central thrombosis, is mostly located in the iliac, femoral and popliteal veins. Due to the thick lumen of the blood vessel, it is easy to dislodge and the thrombus embolizes to the pulmonary artery remotely, which is life threatening. Therefore, once high DVT is diagnosed, thrombolytic and anticoagulant medications should be administered as soon as possible, such as alteplase, urokinase thrombolytic, low molecular heparin, warfarin anticoagulant and so on. Conservative drug treatment should be standardized, sufficient course of treatment (generally not less than 3 months), to maximize the avoidance of complications. Because unstandardized treatment is often easy to lead to fresh thrombosis, the probability of pulmonary embolism is greatly increased. Anticoagulation should not be used or used with caution in cases of recent history of surgery, cerebrovascular accidents, and those with poor coagulation. Vena cava filters should be implanted in these patients if they are at risk for pulmonary embolism. After active treatment and improvement of the symptoms of DVT, it is possible to cure the disease completely with appropriate exercises and treatments for the predisposing factors of the disease, such as prolonged bed rest.