Brittle bone syndrome, or osteogenesis imperfecta, also known as primary bone fragility or periosteal dysplasia, etc., is a rare connective tissue abnormality syndrome characterized by skeletal dysplasia during fetal life. It is characterized by bone fragility, blue sclera, deafness, joint laxity, etc. It is a congenital hereditary pain due to underdevelopment of mesenchymal tissues and impaired collagen formation. The etiology is unknown, it is a congenital developmental disorder with equal incidence in males and females, and it can be categorized into two types: congenital type and delayed type. The congenital type refers to the onset of the disease in utero, and can be subdivided into fetal and infantile type, the condition is serious, is autosomal recessive inheritance; delayed type of the disease is less serious, and can be divided into children and adults, is autosomal dominant inheritance. more than 15% of the patients have a family history. Brittle bone disease is a typical example of genetic variation. Sillence et al. (1979) classified brittle bone disease into four types from the perspective of genogenesis: Type I, autosomal dominant inheritance, with blue sclera, mild to severe bone brittleness, early hearing loss, and dentinogenesis imperfecta; Type II, autosomal dominant inheritance, or dissemination of extreme bone brittleness, with intrauterine fracture, respiratory failure, and newborn death; Type III, autosomal recessive inheritance or dissemination of extreme bone brittleness, with intrauterine fracture, respiratory failure, and newborn death; Type III, autosomal recessive inheritance, or dissemination of extreme bone brittleness; Type III, autosomal recessive inheritance. Type III, autosomal recessive inheritance or autosomal dominant inheritance, moderate to severe bone fragility, obvious bone deformity, scoliosis, different scleral color; Type IV, autosomal dominant inheritance, normal scleral color, mild to moderate bone fragility and deformity, dentinogenesis imperfecta. Clinical manifestations are mainly: 1. Increased bone fragility minor injuries can cause fractures, and severe patients show spontaneous fractures. Congenital type has multiple fractures at birth. Fractures are mostly of the glaucomatous type, with little displacement, mild pain, rapid healing, and reliance on subperiosteal osteogenesis for completion, thus often going unnoticed and resulting in malunion. The long bones and ribs are the most common sites. The deformity caused by multiple fractures further reduces the length of the bone. The tendency to fracture gradually decreases after puberty; 2. Blue sclera accounts for about 90% or more of the cases. This is due to the fact that the patient’s sclera becomes translucent and the color of the choroid beneath it can be seen. There is no abnormality in the thickness and structure of the sclera, and its translucency is due to a change in the nature of the collagenous fibrous tissue; 3. Excessive laxity of the joints, especially the wrist and ankle joints. This is due to the impaired development of collagenous tissue of tendons and ligaments. There can also be knee valgus and flat feet. Sometimes there are habitual shoulder dislocation and dislocation of the radial head, etc.; 4, muscle weakness; 5, head and face deformities, severe craniosynostosis, at birth the head has a sense of skin. Later, the head is broad, the parietal and occipital bones are prominent, the two temporal bulges are bulging, the frontal bone protrudes anteriorly, the ears are pushed downward, and the face becomes an inverted triangle. Some patients are accompanied by hydrocephalus; 6. Dental dysplasia dentition can not be well developed, milk teeth and permanent teeth can be involved. The teeth are yellow or blue-gray, easy to caries and early loss; 7, dwarf, which is due to the development of a slightly shorter than normal, coupled with multiple fractures of the spine and lower limbs due to malformation healing. Currently, the treatment of brittle bone disease mainly includes surgery, drugs, rehabilitation and assistive device adaptation. In this kind of disease, the main auxiliary aids are orthopedic devices, wheelchairs and walkers, which are used to improve the poor bone deformity of children with brittle bone disease, and to improve the weightlessness and gait training. Here we will talk about the use of walking aids in children with brittle bone disease, walking aids can be divided into: alternating walking aids, allowing the patient to support the frame to move forward alternately left and right, alternating steps, suitable for the lower limb muscle weakness, poor balance function; frame walking aids, do not allow alternating left and right movement, must be lifted by the disabled person to lift the frame or forward to put, and then step and move the body, mobility is good, but slow, suitable for the lower limb muscle weakness, balance function is poor. Wheeled walker, divided into two wheels and four wheels, easy to move, used for people with poor muscle strength of the upper limbs, to maintain the balance of the body for training purposes. According to the different categories of walkers, when choosing, the aids fitters and related medical workers should choose the appropriate and suitable ones according to the patients’ upper and lower limb muscle strength and the actual demand of the disease, and then adjust the height fit according to the patient’s own height in order to achieve a better height of the handrail and the stability of the frame. Walking aids are only a small category of many aids, through more research on the disease and more attention to the group, there are more and better medical means of intervention and adaptive aids to make the brittle bones group better integrated into society to realize their own value!