Possible causes of anuria in acute pancreatitis include low blood pressure and shock, and damage to the kidneys by inflammatory substances and toxins; fluid resuscitation is possible for the former, and blood purification is feasible for the latter. 1. Hypotension and shock: When blood flow to the kidneys decreases due to hypotension and shock, urine production decreases, resulting in oliguria and anuria. If there is circulatory dysfunction after the onset of illness, 24 hours is the golden period for fluid resuscitation. The volume and rate of fluid replacement can be adjusted according to the central venous pressure, and it is not advisable to replenish a large amount of fluid. Through active rehydration, the symptoms of anuria can be improved. 2. Inflammatory substances and toxins damage the kidneys: when the patient appears difficult to correct acute renal insufficiency, continuous blood purification through the role of selective or non-selective adsorbents, remove the body’s harmful metabolites or exogenous toxins, to achieve the effect of purifying the blood, the anuria can be improved. Patients with acute pancreatitis who are anuric can inform their physicians in time for rational treatment, and medications should be reasonably applied according to the doctor’s instructions.