Common medicines with great cold include gypsum, Zhi Mu, Scutellaria baicalensis, Huang Huang Lian and other medicines. Gypsum has a sweet, pungent flavor, is very cold in nature, and belongs to the lung and stomach meridians; it is mainly used for its efficacious effects of clearing away heat and fire (removing heat and fire from the body), and removing vexation and quenching thirst. Calcined gypsum used externally has the efficacy of astringing sores and regenerating muscles (helping sores to heal faster and promoting the growth of new flesh), collecting dampness and stopping bleeding. Cold medicines are not suitable for cold body, Yang deficiency, spleen and stomach deficiency (spleen and stomach weakness and cold) and other conditions. Huanglian has the efficacy of clearing heat and drying dampness (removing heat and drying dampness), diarrhea and detoxification (removing fire and poison from the body). Huanglian is cold in nature and bitter in taste, and is a commonly used cold Chinese medicine drink. Huanglian is suitable for the treatment of damp-heat body conditions such as damp-heat, plumpness (stomach distension and discomfort), vomiting, diarrhea, and high fever. It is not suitable for Yin deficiency and fluid injury conditions. Drugs with large cold are mostly used in the treatment of fire, heat and toxicity and other conditions. If the body is particularly weak, cold, yang deficiency and other conditions, it is not recommended to take drugs with large cold. Drugs are recommended to be used under the guidance of a professional doctor to identify the evidence, do not self-medication.