When the hands are exposed to solutions such as salt water or sugar water with high external concentration, or when they are immersed in water for a long period of time, it may cause the hands to lose water and become white and wrinkled, which is generally a normal physiological phenomenon and requires no special treatment. However, if the patient contact with normal water, a shorter period of time can appear white, wrinkled symptoms, may be due to a lack of vitamins in the body, or hypoproteinemia and other disease causes, so need to be identified according to the specific circumstances, can not be determined when it is recommended that timely medical treatment: 1, lack of vitamins: lack of vitamin B, vitamin E, etc. in the body will lead to dry skin, when the hands are swollen and whitening after encountering water will be more When the hands are swollen and whitened by water, it will be more obvious, and the water in the hands will be lost rapidly after leaving the water, so it will lead to wrinkling symptoms. Patients can appropriately consume more vitamin-rich fruits and vegetables, such as cherries, oranges, etc. to relieve; 2, hypoproteinemia: patients with hypoproteinemia generally do not simply have the symptoms of white and wrinkled hands when they touch water. The vast majority of patients will be accompanied by malnutrition, loss of appetite, abdominal pain, diarrhea and other digestive system symptoms. Since hypoproteinemia is a more serious disease, it may be associated with kidney dysfunction. Patients are advised to go to the hospital immediately after the occurrence of the above symptoms for a clear diagnosis and timely relevant treatment to control the disease in order to avoid further deterioration. For patients whose hands appear white and wrinkled when they touch water, they can regularly perform hand care on a daily basis according to their condition, such as using some skin care products with moisturizing effects such as Vaseline and vitamin E to achieve the purpose of moisturizing the skin on their hands.