In the clinical consultation, some patients present with skin disease can also lead to kidney disease, case; a 7-year-old boy, a native of Guangxi, surnamed Wei, caused small boils on his back due to sweating after exercise, and localized pus after not paying attention. The parents thought it was a minor illness and rubbed the medicine at home by themselves without significant improvement. more than 1 month later, the child developed eyelid swelling and hematuria, and the doctor diagnosed it as glomerulonephritis, and the child’s kidney disease was precisely caused by the skin infection triggered by that small boil on his back. Many dermatologists say: “It is not uncommon for skin diseases to lead to kidney disease in clinical practice, mainly because ordinary people lack the appropriate medical knowledge and regard skin diseases as minor illnesses that are not life-threatening, and when they encounter skin discomfort, they think they can apply medicine at will, which results in kidney disease. There are patients who seek medical attention for skin disorders, only to find out that they have serious kidney dysfunction, which regrets missing the best time for treatment. Skin and kidney can not only affect each other, but also be interdependent in kidney and skin syndrome. A large number of clinical studies have confirmed that early diagnosis and treatment of skin diseases can not only prevent nephropathy, but also detect or diagnose nephropathy early to avoid irreversible and lethal nephropathy. Generally speaking, for patients with persistent skin disease or poor treatment, after careful history taking, urine routine and other related tests should be checked to clarify the diagnosis. Nephropathy due to skin diseases, such skin diseases are mainly pyoderma, skin trauma and pruritic skin diseases, the former including diseases such as impetigo, folliculitis and boils, and the latter including eczema, papular urticaria, insect bite dermatitis and tinea pedis. When the body’s resistance is reduced, such as scratching after the skin breaks down, septic cocci such as Staphylococcus aureus and Streptococcus enter the body, and if left untreated, the septic cocci can easily invade the kidneys and cause glomerulonephritis. Skin disorders caused by kidney disease uremia can cause widespread itching, the incidence of which is as high as 86%. Pruritus is associated with dry skin, uremic neuropathy, and the accumulation of nitrogenous substances on the skin surface. In addition, patients with uremia can also cause diffuse brown pigmentation, purpura, and skin calcification. In addition, about 16% of dialysis patients develop blisters and blisters on sun-exposed areas, especially on the back of the hands. Kidney transplant patients are also prone to pathogenic infections such as bacteria, fungi, viruses and skin tumors. Renal and skin syndrome, many diseases can cause simultaneous kidney and skin involvement, some of them belong to the same pathological process, some are determined by the same genetic genes of different organ lesions, these diseases are collectively known as renal and skin syndrome. Generally, they can be divided into two categories: genetic and metabolic disorders. The former are tuberous sclerosis, neurofibromas, hemorrhagic capillary dilation, diffuse somatic angiokeratoma, and congenital ichthyosis-like erythrodermatosis. The latter are mainly systemic amyloidosis, calcium deposits, connective tissue disease, vasculitis, and severe drug rash. Therefore, considering the above factors, it can be said that skin care means kidney care, usually pay attention to personal and environmental hygiene, keep the skin dry and clean, and take care not to use too much alkaline soap, so as not to reduce the protective effect of the skin against external stimuli. Actively treat pruritic skin diseases, avoid scratching, hot water, salt water washing, itching when itching is intense can be taken to stop itching by gently patting with hands, cold compresses. If skin breakage or pyoderma is found, the wound should be cleaned immediately and antibiotic ointment should be rubbed externally. It is worth noting that clothing, towels and toys used by patients with skin diseases should be promptly ironed, boiled, exposed to the sun or disinfected with disinfectant solution. Infants, elderly and frail patients, patients with diabetes, severe liver dysfunction, tumors and chronic wasting diseases should be promptly seen by a hospital to avoid aggravation.