Abstract: OBJECTIVE: To study the clinical efficacy of Ge Gen Er Teng Tang in the treatment of vertebral artery type cervical spondylosis. Methods: x cases were randomly divided into treatment and control groups and randomly administered. The overall efficacy of the treatment and control groups was evaluated before and after taking the medication, and color Doppler and transcranial Doppler were introduced as efficacy evaluation criteria, and statistical analysis was performed on the indexes of the patients before and after taking the medication. Conclusion: The clinical efficacy of Ge Gen Er Teng Tang in the treatment of vertebral artery cervical spondylosis was obvious, and the indexes of TCD and CDFI changed significantly. Hao Yanke, Department of Spinal Orthopedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Keywords Cervical spondylosis, Chinese medicine therapy, Ge Gen Er Teng Tang, TCD, CDFI
Cervical spondylosis is one of the persistent orthopedic diseases, which seriously affects the health of middle-aged and elderly people, and is therefore included in the key topics of the 8th Five-Year Plan, while about x% of patients with cervical spondylosis seen in clinical practice have vertebral artery involvement. The disease mostly occurs in middle-aged and older patients, and its incidence has been on the rise in recent years. From 20xx to 20xx, x cases of vertebral artery cervical spondylosis were treated with “Ge Gen Er Teng Tang” formulated by Professor Cao Yixun of Shandong University of Traditional Chinese Medicine, and good results were achieved. In this study, we intend to compare the efficacy of Ge Gen Er Teng Tang and Cipro on vertebral artery cervical spondylosis by comparing the changes of TCD and CDFI parameters and the improvement of clinical symptoms before and after taking the medicine. The results are reported as follows
1 Clinical data
1.1 Observed x cases, all of which were outpatient and ward cases. The randomized double-blind method was used to divide into treatment group (Ge Gen Er Teng Tang group) and control group (Cipro Ling group)
Treatment group: x cases in male, x cases in female. The maximum age was x years, the minimum age was x years, and the average age was x years. The shortest duration of disease is x months, the longest is x years, the average is x years.
Control group: male x cases, female x cases. Maximum age x years, minimum age x years, average age x years. The shortest duration of disease is x months, the longest is x years, and the average is x years.
1.2 TCD detection method
Transcranial color Doppler analyzer was used, the patient was seated with head tilted forward, the probe was placed at the occipital foramen to probe both vertebral arteries and basilar arteries, and the peak systolic flow velocity (Vs), end-diastolic flow velocity (Vd) and mean flow velocity (Vm) of the vessels were observed.
1.3 CDFI detection method
For color Doppler examination, the subject was placed in the horizontal position, and the C3/4C4/5C5/6 segments of the patient’s vertebral artery were measured separately. The intravascular diameter (D), peak systolic flow velocity (PSV), end-diastolic flow velocity (EDV) blood flow per minute and resistance index (RI) were measured.
1.4 Diagnostic criteria: refer to the Diagnostic Efficacy Criteria for Chinese Medicine Conditions with chronic strain injury, history of trauma or degenerative lesions of the cervical spine; neck, shoulder and back pain, headache and dizziness, stiffness of the neck plate, numbness of the upper limbs; limited function of neck movement, lesioned cervical spinous process, frequent pressure pain in the internal superior angle of the affected scapula, positive brachial plexus pull test, positive head press test; X-ray and/or CT showed pathological changes
1.5 TCD, CDFI normal criteria
Age 35-68, basilar artery (BA) systolic (Vs) flow velocity is 58.4cm/s, diastolic (Vd) flow velocity is 27.7cm/s mean flow velocity (Vm) is 44.4cm/s, pulsatility index (PI) is 0.78; vertebral artery (VA) right Vm 41.8cm/s, Vs 49.1cm/s, Vd 23.2cm/s, PI Ultrasound diagnostic criteria of our normal human neck vascular ultrasound parameters, the internal diameter of the vertebral artery (VA)