Choice of drug solvents: saline or glucose? Depending on the specific conditions of the patient I. Depending on the patient’s primary disease and its complications: 1. If the patient has hypertension, coronary artery disease and cardiac insufficiency, the intake of saline should be reduced to reduce the burden on the heart. 2.If the patient has diabetes mellitus but heart and kidney function is still okay, saline can be used, but when using sugar water, insulin can be added proportionally to neutralize sugar. 3, such as the patient’s renal insufficiency, to reduce the intake of sodium and water, to reduce the sodium water storage slip. Second, according to the patient’s laboratory results. 1, electrolyte results, with hyponatremia, give saline, and vice versa with sugar. 2, according to cardiac enzymes and other assessment of cardiac function, according to which to decide the choice of salt and sugar. Saline is mainly used for electrolyte regulation, while sugar is mainly used as energy, and this should be taken into account first when choosing. The choice of solvents for antibiotics is still mainly based on stability considerations. In the preparation, glucose in the production process need to add hydrochloric acid, the finished solution PH is mostly about 3, while saline is slightly higher, generally 4 ~ 5. 1, β-lactams in nearly neutral (PH = 6 ~ 7) solution is more stable, acidic or alkaline solution are easy to make β-lactam ring open ring, lose antibacterial activity, so you should choose saline Do solvents. 2, macrolide antibiotics in alkaline conditions antibacterial efficacy than acidic conditions can be enhanced by more than 10 times (there are relevant research reports), it is recommended to choose salt as the solvent, or in the solvent to add sodium bicarbonate to improve the PH value. 3, penicillins are more stable in near-neutral (PH=6-7) solution, acidic or alkaline solution will accelerate its decomposition, it is best to use water for injection or isotonic sodium chloride injection to dissolve penicillins when applied. Dissolved in glucose solution (PH=3,5~5,5) can have some degree of decomposition. Penicillins decompose extremely quickly in alkaline solutions. Therefore, it is strictly forbidden to match alkaline solutions (sodium bicarbonate, aminophylline, etc.) with them. 4, synthetic antibiotics such as metronidazole due to the specificity of its molecular structure, 5% glucose solution is more stable than the shape of physiological saline. 5, quinolones, such as levofloxacin, especially pefloxacin, should be used with sugar water. Pefloxacin cannot see chloride ion, otherwise it will form a precipitate.