Urinary tract infections (UTIs) are a general term for microbial infections that occur anywhere in the urinary tract, from the urethra to the kidneys.UTIs occur in people of all ages and are the most common cause of sepsis in the elderly. With the gradual increase in human life expectancy, the incidence of various infectious diseases is significantly higher in the elderly, and the prevalence of UTI is second only to respiratory tract infections in the elderly population aged >65 years. Elderly patients are clinically characterized by complex etiology, many influencing factors, atypical symptoms, heavy disease, and prolonged disease. In recent years, although antimicrobial drugs are commonly used for treatment and prevention, the recurrence and reinfection rates have not been significantly reduced due to changes in the pathogenic spectrum of pathogenic bacteria and the emergence of drug-resistant strains. In particular, it is very difficult to prevent and treat patients with complex urinary tract infections such as abnormal urinary tract function, urinary tract obstruction, reflux, and suffering from systemic immune or metabolic diseases. Therefore, we need to continuously improve the prevention and treatment of urinary tract infections in the elderly. Longer courses of antibiotics are effective in reducing the recurrence of UTIs in older women. In older women with 2 infections in 6 months or 3 or more infections in 12 months who are symptomatic, prophylaxis should be continued until the infection is eradicated. Most experts recommend 1 dose per night for 6 months, and some recommend continued prophylaxis for years. Antibiotics used for prophylaxis include methotrexate and sulfamethoxazole, furantoin, and cephalosporins. Severe prostate enlargement is a risk factor for UTI in older men, and partial prostatectomy can help reduce recurrence of infection. Cranberry juice or capsules prevent E. coli and other gram-negative bacteria from adhering to the host cell surface. Different types of adhesins on the cilia of E. coli or other bacteria can adhere to epithelial cells, and the unique compound component of cranberry, proanthocyanidin, inhibits the adhesion process. Measures to prevent indwelling catheter infection are currently recognized by most scholars: 1. Use indwelling catheters in the bladder only when absolutely necessary, shorten their retention time as much as possible, and patients with long-term indwelling catheters should be replaced in a timely manner according to the patient’s condition; 2. Keep the catheter system airtight and open the system only when obstruction occurs and requires flushing; 3. The urine bag should be fixed in a position lower than the bladder to prevent Once infection occurs, immediately remove the indwelling urinary catheter or replace it with a new urinary catheter system, and at the same time, strengthen strict disinfection measures and carefully control each link; if the catheter is indwelling for more than 7 d, it should be removed first and then treated with antibiotics; 5. 7. Catheters injected with antibiotics may reduce the incidence of asymptomatic bacteriuria within 1 week, but will not reduce symptomatic infections and are therefore not recommended for routine use; 8. Catheters made of silver alloy significantly reduce asymptomatic bacteriuria within 1 week and have been shown to reduce the incidence of symptomatic UTIs; 9. The catheter should be removed before midnight if possible.