Treatment of childhood akathisia seizures begins with determining whether the type of seizure in children is a true akathisia seizure. A typical akathisia seizure is a 3Hz/s spike wave, and an atypical one may be a 2.5-3Hz/s spike wave that manifests as a sudden freezing of the eyes without moving. If a childhood akathisia seizure is identified, the preferred drugs for treatment are recommended to be ethosuximide and sodium valproate as the drugs of choice, and if a generalized tonic clonic seizure occurs, sodium valproate should be preferred. However, some children, such as girls approaching prepubertal age, are not recommended to use sodium valproate because it may affect endocrine or future fertility, and some older children may gain weight when taking sodium valproate, so they should choose ethosuximide at this time. If neither of them is suitable, such as ethosuximide and sodium valproate or ineffective, or if more serious side effects occur after using them, lamotrigine can be considered. If neither of the two first-line drugs is effective, you may consider choosing two of ethosuximide, sodium valproate and lamotrigine, or a combination of the three drugs. If there is still no effect, or in case of serious side effects, consider applying clobazam or clonazepam, levetiracetam, topiramate, etc. The choice of drugs is wider.