After Dapoxetine is discontinued, the patient’s premature ejaculation is usually not more serious, but there is a risk of rebound. Dapoxetine is a selective 5-hydroxytryptamine reuptake inhibitor, which can inhibit the sensitivity of the sensory nerve endings of the glans and increase the ejaculation threshold, thus prolonging the ejaculation latency time. When the patient stops using the drug the synaptic gap 5-hydroxytryptamine concentration will gradually decrease, the patient’s ejaculation threshold will return to the original level. Premature ejaculation is divided into physiological factors and pathological factors, for some mainly psychological factors leading to premature ejaculation, dapoxetine treatment is more effective, according to the doctor’s orders to stop the drug rebound probability is small; if it is due to the sensitivity of the glans and so on the premature ejaculation, due to the discontinuation of the drug after the sensitivity of the glans may be restored again, and therefore may reappear premature ejaculation. Dapoxetine discontinuation should be carried out under the guidance of a doctor. If symptoms progress, seek medical attention.