2010 is quietly gone, 2011 is gladly coming. Lunar New Year’s movie is also coming at this time, which attracts people’s attention more than Feng Xiaogang and Wang Shuo jointly launched the “Do Not Disturb 2”, the film’s most powerful supporting role belongs to Sun Honglei played Li Xiangshan. The character because of the back of the foot a small black spot and fell into the sea to commit suicide, can not be said not sad, can not be said not pathos. However, malignant melanoma really “the world can not take it”? “Moles have to hurry to point out”? The author boasts nearly 20 years of experience in the diagnosis and treatment of melanoma, and reminds us that there is a misunderstanding of melanoma and the relationship between moles and melanoma in “Not 2”. Let’s briefly introduce malignant melanoma. This tumor accounts for the third place of skin malignant tumors, originates from skin melanocytes, and has the characteristics of high aggressiveness, high metastasis, high mortality, and insensitivity to both radiotherapy and chemotherapy, so it is very harmful to the human body. Myth 1: Melanoma, the world can’t do anything about it. Early treatment of malignant tumors has definite curative effects, and melanoma is no exception. The earliest melanoma (melanoma in situ) can be completely “cured” after surgical resection. Even if the melanoma has metastasized and developed into a more advanced tumor, even if the tumor is not sensitive to radiotherapy and chemotherapy, we can greatly improve the survival rate and quality of life of the patients through active means of combined application of surgical, biological and immunotherapy, and encouraging results have already been achieved. Therefore in reality, the majority of melanoma patients do not need to panic and give up, and should cope with it with a positive and optimistic attitude. It is a big mistake for Mr. Li Xiangshan to give up treatment and wait for death with dignity in “Not 2”, which undoubtedly condones the spreading and proliferation of tumors and contributes to the occurrence of tragedy. Myth 2: If you have a nevus, you have to point it out quickly. “Nevus” is the common name of pigment mole, is a general term for benign melanocyte tumors, almost everyone’s skin has a pigment mole, only the number and location of different, some of the pigment moles occurring in the face will affect people’s beauty, so the “point mole” is very popular. At present, medical institutions apply the “mole” method is only laser, freezing, chemical corrosion and other methods, these methods not only have the risk of recurrence, scarring, more serious is that it may lead to pigmented nevi malignant melanoma. Therefore, malignant melanoma is closely related to pigmented nevus, and part of malignant melanoma comes from improper treatment of pigmented nevus, i.e. “mole spotting”. In addition, the probability of malignant transformation of pigmented nevi in some friction areas and easily irritated areas is significantly higher than that in other areas, such as the back of the foot and the sole of the foot, instead of the back of the foot as shown in “Not 2”. Therefore, the best way to deal with pigmented nevus is not to “point” the nevus, but to “cut” the nevus, i.e. surgical excision plus pathological biopsy, which can not only prevent early melanoma misdiagnosed as pigmented nevus leading to delayed condition, but also prevent malignant transformation of pigmented nevus and achieve the purpose of cosmetic treatment. In conclusion, we call for the treatment of nevus should be: no treatment is already, treatment is thorough. Conclusion: Who would have thought that a New Year’s comedy movie would cause such a storm in the medical field, people should look at health problems objectively and scientifically while laughing. Although melanoma is difficult to treat, it is by no means untreatable, early diagnosis and early treatment is the key; nevus can be malignant to melanoma, we can preventively “excise” congenital nevus, prohibit the use of lasers, freezing, corrosion, and other “pointing” method of nevus treatment. We strongly urge: moles are not to be disturbed; if they are disturbed, then they should be cut!