Multiple myeloma, a type of malignant plasma cell disease that can be abbreviated as MM based on the first letter of the alphabet, is one of the most misdiagnosed types of hematologic diseases. Patients are mostly referred from orthopedic and nephrology departments. The disease occurs mainly in middle-aged and elderly patients, according to our statistics, the average age is around 60 years old, patients under 40 years old are rare, and those under 30 years old are even rarer, but the incidence tends to rise with age. Common clinical manifestations 1. Skeletal pain: The most common symptom, the common pain site is the low back, thoracic rib area. Sometimes patients make the mistake of going to Chinese medicine for physical therapy and massage, because the disease causes patients to have extremely osteoporotic bones, which can lead to paralysis during massage due to vertebral fractures and compression of nerves, a complication that seriously affects the quality of life. 2. Anemia and bleeding tendency: There is often dizziness, weakness, tinnitus, and pallor. If recurrent subcutaneous bleeding occurs, ocular prevalence is often indicative of disease progression. 3, renal insufficiency: manifested as foamy urine, swelling, examination suggesting proteinuria, renal insufficiency. Therefore, patients often go to the nephrology department, and generally the nephrologists in large general hospitals will remind patients to go to the hematology department to investigate myeloma. 4.Recurrent infection: It can be the first symptom of some patients, which is due to the damage of immune system and low resistance; repeated infections can also promote the progression of myeloma. 5. Hypercalcemia: It can cause headache, vomiting, polyuria, etc. 6. Hyperviscosity syndrome: There may be numbness in hands and feet. According to the above main manifestations, if you have dizziness and weakness (anemia), back pain, more than 2 respiratory and urinary tract infections in a year, numbness of hands and feet, etc., especially if you are over 50 years old, it is recommended to go to the hospital for screening of multiple myeloma. Patients who have regular medical checkups are also recommended to undergo screening for multiple myeloma if they have low hemoglobin in routine blood tests, positive (+) or suspicious (±) protein in routine urine tests, or high or low globulin in liver function.