Fatty liver disease is the second most common liver disease after viral hepatitis. Non-alcoholic steatohepatitis (NASH) is a clinicopathological syndrome characterized by excessive fat deposition in hepatocytes, excluding alcohol and other definite liver-damaging factors, and is a metabolic stress liver injury closely related to insulin resistance and genetic susceptibility. alcoholic simple fatty liver, nonalcoholic steatohepatitis and its associated cirrhosis and hepatocellular carcinoma. With the global epidemic of obesity and metabolic syndrome, the prevalence of NAFLD has been growing rapidly and at a low age in the past 20 years, with the prevalence of adult NAFLD reaching 10-30% in developed regions such as Shanghai, Guangzhou and Hong Kong in China, and no ideal therapeutic drugs are available. Non-alcoholic fatty liver disease is a new challenge in contemporary medicine, and its risk to human health will continue to increase. The combination of acupuncture and medicine in the treatment of fatty liver disease creatively selects three traditional Chinese medicines (three flavors of fat elimination formula) with acupuncture to treat fatty liver disease with low price, precise efficacy, good safety and easy operation. The efficacy of the treatment has brought a boon to the current situation that the incidence of fatty liver disease is increasing and the incidence is getting younger. Patients will undergo physical examination, vital signs measurement, routine safety laboratory and nutrition laboratory assessment, routine, biochemical, metabolic and immunological tests, and imaging examinations, based on a combination of needle and drug treatment, supplemented by nutritional and exercise interventions to improve the treatment of non-alcoholic fatty liver disease. This technology will give full play to the advantageous features of cheap, convenient, simple and experimental to benefit the working class and solve the problem of difficult access to medical care.