Patients with diabetic peripheral neuropathy should first clarify the type of diabetes: patients with type 1 diabetic peripheral neuropathy use insulin to control blood glucose under the guidance of a doctor; patients with type 2 diabetic peripheral neuropathy can take oral hypoglycemic drugs to control blood glucose under the guidance of a doctor, such as biguanide, glargine hypoglycemic drugs, and can also use insulin to control blood glucose. Patients with type 1 diabetes mellitus peripheral neuropathy: insulin must be used to control blood glucose, such as long-acting insulin glucagon, short-acting insulin menthyl, etc. The diagnosis and treatment plan should be formulated by the professional doctor according to the blood glucose situation. Medications for patients with type 2 diabetes mellitus peripheral neuropathy: insulin can be used to control blood glucose, but also oral hypoglycemic drugs to control blood glucose, such as biguanide, on behalf of the drug metformin; α-glucosidase inhibitors, on behalf of the drug acarbose; sulfonylureas, on behalf of the drug glimepiride, and so on, the specific use of drugs should be formulated by a professional doctor according to blood glucose situation. Diabetes mellitus patients’ blood glucose control target: fasting: 4.4~7.0mmol/l, postprandial <10.0mmol/l, glycated hemoglobin <7.0%; older people can be appropriately relaxed to reduce the risk of hypoglycemia. Diabetic peripheral neuropathy patients with poor glycemic control, need to go to the hospital as soon as possible, by the physician according to the specific conditions, to formulate individualized diagnosis and treatment plan, so as not to delay the condition.