Moles on the hands may be pigmented nevi, if they are red and fade when pressed, they are considered to be spider nevi, which may be caused by viral hepatitis, cirrhosis of the liver and other diseases, and need to be treated with medication, surgery, physiotherapy, and so on. If it is a spider nevus caused by physiological factors and a pigmented nevus that does not affect the aesthetics, there is no need for treatment. 1. Pigmented nevus: It is mainly manifested as a patchy rash or papule with clear boundary and even color at the lesion, and the color can be brown, brown and so on. For larger pigmented nevus, it is necessary to consider removing it through surgery, but for smaller pigmented nevus, YAG laser and CO2 laser can be considered for physical treatment. 2. Viral hepatitis: common symptoms include greasiness, fatigue, pain in liver area, spider nevus and so on. Patients need to apply antiviral drugs, such as entecavir, tibivudine, ribavirin, sofosbuvir, polyethylene glycol interferon, etc., as well as liver-protecting drugs such as magnesium isoglycyrrhizinate, glutathione, etc., and some patients need to apply immunomodulators such as thymus pentapeptide and thymosin, etc., in accordance with the prescription of the doctor. For patients with severe hepatitis, artificial liver support system or liver transplantation should be considered. 3. Cirrhosis: Typical symptoms include fatigue and loss of appetite. Patients should use antiviral drugs such as entecavir, tenofovir, daclatasvir, etc. as prescribed by doctors. For the end stage of cirrhosis, patients need to consider liver transplantation or splenectomy. If the mole on the hand is caused by pregnancy, it does not require any special treatment. Secondly, moles that do not affect the aesthetics of the skin do not need to be treated. It is recommended that people with moles on their hands go to the hospital to find out the exact cause of the moles, and cooperate with the doctor for active treatment if necessary.