Diabetes mellitus causing uremia need to continue to use insulin treatment, please follow the doctor’s instructions. Diabetic patients with long-term poor glycemic control will induce diabetic nephropathy, and when diabetic nephropathy further progresses, it can develop into uremia, and at this time, it is necessary to consider dialysis and other renal replacement therapy. However, at the same time, glucose-lowering treatment is still needed, such as insulin injection, combined with dietary control and appropriate exercise to maintain blood glucose within a reasonable range. Patients diagnosed with diabetes mellitus with uremia should actively cooperate with the doctor to adjust the dosage of medication according to the specific condition, and should not blindly stop taking the medication on their own to avoid adverse consequences.