Cold and flu granules are a combination of Chinese and Western medicine. The adverse reaction item in the drug’s instruction suggests that rash, urticaria, drug fever and granulocytopenia are occasionally seen; drowsiness, drowsiness, thirst and weakness are seen, and long-term heavy use of the drug can lead to abnormal liver and kidney functions. Coldspring granules are composed of tridentate bitter, marigold silver plate, wild chrysanthemum, gomphocarpus, caffeine, acetaminophen, paracetamol and peppermint oil. The caffeine, acetaminophen and paracetamol in the ingredients can cause adverse reactions in human body in different degrees. For example, acetaminophen has been reported in the past [1] to cause severe liver damage, herpetic rash, and even coma in some cases due to the abuse of this drug. Another example is paracetamol, also known as chlorpheniramine, which has a central depressant effect and tends to cause drowsiness. It is believed in the literature that most patients will experience drowsiness, lack of concentration, aggravation of coronary heart disease, increased blood pressure and other symptoms after taking anti-cold compound preparations like cold and flu granules. If these drugs are abused, they may cause certain hematological diseases, such as granulocytopenia, hematuria, aplastic anemia, etc. If patients take these anti-cold drugs for a long time, it is likely to cause gastric ulcer, gastric bleeding, urticaria, allergic rash, skin rash, etc. If it is serious, exfoliative dermatitis, herpetic epidermolysis bullosa, etc.. If patients take these drugs in large doses, they can damage the liver, which can cause coma and death in serious cases. A comparative study of the drowsiness effect of common Chinese and Western cold medicines was done in the literature, and it was concluded that the drowsiness effect of Chinese medicines is not obvious, and the drowsiness effect of the combined Chinese and Western medicines is obvious, and the Western medicines are the most obvious. The side effects of drowsiness caused by the combination of Chinese and Western medicines are obvious.