Headache and nausea when staying up late are mostly seen in patients with migraine. Patients with migraine tend to have headache, nausea, drowsiness, fatigue and irritability after staying up late, lack of sleep, overuse of the brain, anger, exertion, emotional excitement and cold. The headache can be predominantly frontotemporal top, periorbital or retroorbital at one time or bilaterally, gradually expanding to the whole head with paroxysmal throbbing, swelling or throbbing pain that lasts for minutes, days or hours to relieve. Some people can have visual aura, including blurred vision, distorted vision, visual defects, flashes of light, bright spots, water ripples, or jagged changes, and some people can have a family history. Headache attacks can be relieved by sleeping and applying related medications, such as painkillers to relieve the pain, such as ibuprofen, Xanax, meloxicam, etc. Specific pain medications, such as ergotamine preparations and treprostans, can also be applied when the headache is severe. Avoiding late night, cold, strain, overuse of brain, keeping emotional stability, etc., are important measures to prevent and relieve migraine.