Many hepatitis B virus carriers give up anti-fibrotic treatment after they learn that they are not suitable for antiviral treatment for the time being; many other patients have been found to have liver fibrosis but do not pay attention to it and are unwilling to undergo treatment, thinking that there is no need to treat it without any symptoms and that treatment is a complete waste of money and time. These patients with liver disease should understand what is liver fibrosis and what is cirrhosis in order to seek a more desirable clinical outcome, improve quality of life and prolong life expectancy. ”Liver fibrosis is cirrhosis” is a misconception that many people would have, but it is not. Liver fibrosis and cirrhosis are two different pathological stages of chronic liver disease that manifest themselves in the evolution of the disease. There are many clinical causes of liver fibrosis, and all kinds of chronic liver damage can cause liver fibrosis, which can be divided into two kinds: congenital and secondary. Congenital liver fibrosis is less common, while secondary causes of liver fibrosis include viral hepatitis, schistosomiasis, alcoholic hepatitis, non-alcoholic steatohepatitis, autoimmune hepatitis, drug-related hepatitis, and primary biliary cirrhosis. Liver fibrosis is a common and frequent disease in China. So, what is liver fibrosis all about? Let’s make a common analogy, join the skin on the surface of our body is broken, there will be a wound, and when the wound grows, it will leave a scar. This scar is formed by fibrous tissue, and the process of scarring is called fibrosis. If the wound is small and the incision is neat, the defective part is mainly repaired by the original skin tissue proliferation, the formed scar is small and the degree of fibrosis is light; on the contrary, the wound is large and the incision is not neat, the defective part has to be filled by fibrous tissue, so the formed scar is large and the degree of fibrosis is heavy. The liver fibrosis situation is similar to this scarring process, except that the site of scarring is in the liver. The hepatocytes damaged by inflammation in the liver are cleared by the body after necrosis, and the defective area is lightly or even invisibly fibrotic if it is repaired by proliferating hepatocytes; the defective area is more heavily fibrotic if it is filled by proliferating fibrous tissue; if the fibrous tissue keeps proliferating and invades into the liver tissue, it destroys the structure of normal liver tissue and forms many cords or encapsulated nodules. The texture of the liver becomes hard, and this is cirrhosis. It can be seen that fibrosis is the “bridge” to cirrhosis, and it can also be said that the relationship between liver fibrosis and cirrhosis is a quantitative to qualitative change. Therefore, if detected early and measures are taken to stop the discovery of fibrosis, the emergence of cirrhosis can be prevented. Mild liver fibrosis is completely reversible, and if it is treated aggressively and the onset and progression of fibrosis is terminated in a timely manner, cirrhosis may be avoided. The relationship between liver fibrosis and cirrhosis is like the relationship between precancerous lesions and cancer. If liver fibrosis is treated properly, the development of cirrhosis can be avoided, just as timely treatment of precancerous lesions can prevent cancer. If liver fibrosis is not prevented, it will be more difficult to treat it after it is transformed into cirrhosis.