Mother-to-child transmission is one of the important routes of transmission of hepatitis B. Therefore, mother-to-child interruption is particularly important. Blockage of mother-to-child transmission of hepatitis B virus: 1. Pregnancy: The high load of hepatitis B virus is the main reason for postpartum immunization failure. China’s “Guidelines for the Prevention and Treatment of Chronic Hepatitis B” state that antiviral treatment is the key. For HBV-DNA greater than 106 pregnancy can be applied antiviral therapy. Tebivudine is a class B drug of the FDA, but informed consent is required. 2. At the time of delivery: The mode of delivery has no significant effect on the mother-to-child transmission of hepatitis B. However, for prolonged labor, timely treatment is required. However, prolonged labor requires prompt management. 3. Postpartum: Newborns should be immunized promptly with active and passive immunization. Within 24 hours after birth (the earlier the better), HBIG 20IU is injected intramuscularly, and hepatitis B vaccine (recombinant yeast 10ug or CHO 20 ug) is administered according to the 0, 1, 6 protocol. Hepatitis B markers are tested at 7 months of age to determine whether immunization is successful.