Drinking lemonade and experiencing chest tightness may be caused by the stimulating effect of lemonade on the gastrointestinal tract, or it may be a sign of heart disease. Lemonade is highly acidic, after drinking it may have an irritating effect on the mucous membrane tissue of the gastrointestinal tract, if you drink too much lemonade or too fast, there may be epigastric pain, sometimes accompanied by chest tightness. Patients with heart disease drink lemonade, if the coronary artery spasm leads to myocardial ischemia, may produce chest tightness symptoms, and will continue to aggravate, and dizziness, fatigue and other manifestations. Drinking lemonade after the symptoms of chest tightness, the need for appropriate rest and active observation, for the symptoms of persistent chest tightness, must be timely medical examination and treatment.