Giant cell tumor of bone is a benign aggressive tumor of bone primary, accounting for 20% of primary bone tumors, which was classified as low-grade malignant in the early stage, then as intermediate malignant, and now the classification is benign aggressive tumor stage III. The preferred sites are the lower femur and upper tibia, i.e., around the knee joint, followed by the proximal humerus and distal radius, and other sites are vertebrae, sacrum, ilium, proximal fibula, and distal tibia. The main manifestation is local pain, which gradually worsens, and with the progress of the disease, there may be swelling and pressure pain. If a fracture occurs, it manifests as sudden severe pain, swelling, deformity, and impaired movement. The cause of fracture is often a minor trauma, without significant systemic manifestations such as fever and wasting.